Repair & recovery

TB-500

A short fragment of thymosin beta-4, a peptide connected with cell structure and movement.

A fragment of thymosin beta-4.

This reference covers the seven-amino-acid fragment Ac-LKKTETQ identified as TB-500. Its sequence comes from the actin-binding region of thymosin beta-4. Actin helps cells maintain their shape and move.

How it works.

Peptide sequence: Ac-LKKTETQ: seven amino acids with an acetyl group at the beginning of the chain.
Actin-binding region: This sequence comes from the actin-binding region of thymosin beta-4.
Cell structure: Actin forms part of the cell’s internal framework and contributes to shape, movement, and cell division.

Useful terms

Fragment: A shorter sequence taken from a larger peptide or protein.
Actin: A protein that forms structural filaments within cells.
Acetylation: The addition of an acetyl chemical group to a molecule.

Results.

Cell & tissue experiments · related sequence

Cell movement and vessel sprouting.

Experiments with the seven-amino-acid actin-binding sequence from thymosin beta-4 found increased movement of human blood-vessel cells and vessel sprouting in chick tissue. These findings describe the sequence’s biological activity.

Actin-binding sequence · Philp et al., 2003

Risks, concerns & drawbacks.

Know the exact molecule: The seven-amino-acid fragment and full-length, 43-amino-acid thymosin beta-4 are different molecules. Check the sequence when comparing products or results.
Human side effects: The fragment experiments cited here do not establish human side-effect frequencies or the effects of repeated, long-term use.

TB-500 identity · Esposito et al., 2012 Fragment experiments