Longevity, sleep & cognition
Selank
A seven-amino-acid peptide connected with GABA signaling and the regulation of anxiety.
A connection with GABA signaling.
GABA is a chemical messenger that helps quiet nerve-cell activity. In laboratory work using rat brain membranes, Selank changed GABA binding in a way consistent with strengthening that signal.
How it works.
- GABA binding
- In brain membrane experiments, Selank increased binding of GABA, a major inhibitory neurotransmitter.
- Allosteric modulation
- An allosteric modulator changes receptor activity through a site separate from the main transmitter-binding site.
- Inhibitory signaling
- GABA signaling helps regulate the excitability of neurons.
Useful terms
- Heptapeptide
- A peptide containing seven amino acids.
- GABA
- Gamma-aminobutyric acid, a major inhibitory chemical messenger in the brain.
- Neurotransmitter
- A chemical messenger used by nerve cells.
Results.
Risks, concerns & drawbacks.
- Side-effect detail
- The published trial summary does not give side-effect frequencies. Uncommon reactions and the effects of repeated long-term use remain open questions.
- Medication combinations
- The study compared Selank with medazepam; it did not establish how Selank interacts with other anxiety medicines taken at the same time.